Theopold U, Dal Zotto L, Hultmark D
Department of Molecular Biology, Stockholm University, Sweden.
Gene. 1995 Apr 24;156(2):247-51. doi: 10.1016/0378-1119(95)00019-3.
A cDNA, coding for the first Drosophila melanogaster homolog of a family of proteins (FK506-binding proteins, FKBPs) which bind to the immunosuppressive drug FK506, was isolated. The deduced aa sequence corresponds to a 39-kDa product (FKBP39) which, besides a domain with similarity to FKBPs, has a highly charged domain with two strongly acidic stretches. The transcript could be detected in all developmental stages, with the highest expression in the embryo. In adult flies, the strongest signal was detected in the ovaries. Although the FKBP39 gene is expressed in the immunocompetent D. melanogaster blood cell line, mbn-2, the antibacterial defense reaction of these cells is unaffected by FK506.
分离出了一种编码果蝇中首个与免疫抑制药物FK506结合的蛋白质家族（FK506结合蛋白，FKBPs）同源物的cDNA。推导的氨基酸序列对应于一种39 kDa的产物（FKBP39），该产物除了有一个与FKBPs相似的结构域外，还有一个带有两个强酸性片段的高电荷结构域。在所有发育阶段都能检测到该转录本，在胚胎中表达量最高。在成年果蝇中，卵巢中检测到的信号最强。尽管FKBP39基因在具有免疫活性的果蝇血细胞系mbn-2中表达，但这些细胞的抗菌防御反应不受FK506的影响。
