Kimura H, Tooyama I, McGeer P L
Division of Neuroanatomy, Shiga University of Medical Science, Otsu, Japan.
Tohoku J Exp Med. 1994 Nov;174(3):279-93. doi: 10.1620/tjem.174.279.
Immunohistochemical examination of postmortem brain tissue of Alzheimer's disease revealed that acidic fibroblast growth factor (aFGF) was specifically expressed in a subpopulation of reactive astrocytes which were congregated at the margin of the senile plaque. Double immunostaining indicated that such upregulation of aFGF expression might be related to the presence of reactive microglia rather than beta-amyloid protein deposits. Although, on the other hand, immunohistochemical staining for fibroblast growth factor receptor-1 occurred in some cortical neurons of Alzheimer's disease, the staining pattern did not differ from that in age-matched controls. Possible significance of aFGF-positive astrocytes in the surroundings of the senile plaque will be discussed in relation to receptor mediated or non-mediated mechanisms.
对阿尔茨海默病患者死后脑组织进行免疫组织化学检查发现，酸性成纤维细胞生长因子（aFGF）在聚集于老年斑边缘的一群反应性星形胶质细胞中特异性表达。双重免疫染色表明，aFGF表达的这种上调可能与反应性小胶质细胞的存在有关，而不是与β淀粉样蛋白沉积有关。另一方面，虽然在阿尔茨海默病的一些皮质神经元中出现了成纤维细胞生长因子受体-1的免疫组织化学染色，但染色模式与年龄匹配的对照组没有差异。将结合受体介导或非介导机制讨论老年斑周围aFGF阳性星形胶质细胞的可能意义。
