阿尔茨海默病患者大脑中的酸性成纤维细胞生长因子样免疫反应性

Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients.

作者信息

Tooyama I, Akiyama H, McGeer P L, Hara Y, Yasuhara O, Kimura H

机构信息

Institute of Molecular Neurobiology, Shiga University of Medical Sciences, Otsu, Japan.

出版信息

Neurosci Lett. 1991 Jan 2;121(1-2):155-8. doi: 10.1016/0304-3940(91)90673-h.

DOI:10.1016/0304-3940(91)90673-h

PMID:1708473

Abstract

Localization of acidic fibroblast growth factor (aFGF)-like immunoreactivity was examined in postmortem human brain tissue of Alzheimer and age-matched control cases using a rabbit polyclonal antibody specific for aFGF. In control cases, a small number of glial cells were stained very weakly in white but not in gray matter. In Alzheimer cases, some astrocytes were strongly stained for aFGF in both gray and white matter. These intensely staining cells were frequently observed surrounding senile plaques, but represented a small proportion of the total astrocytic population. The present study suggests that aFGF may be upregulated in areas of Alzheimer pathology.

摘要

使用针对酸性成纤维细胞生长因子（aFGF）的兔多克隆抗体，对阿尔茨海默病患者及年龄匹配的对照者的尸检脑组织中aFGF样免疫反应性进行了定位研究。在对照病例中，少量神经胶质细胞在白质中染色非常微弱，而在灰质中则无染色。在阿尔茨海默病病例中，一些星形胶质细胞在灰质和白质中均被aFGF强烈染色。这些强染色细胞经常在老年斑周围观察到，但仅占星形胶质细胞总数的一小部分。本研究表明，aFGF可能在阿尔茨海默病病理区域中上调。