Soulillou J P, Peyrat M A, Guenel J
Lancet. 1978 Feb 18;1(8060):354-6. doi: 10.1016/s0140-6736(78)91081-4.
In 18 kidney-allograft recipients the post-transplant appearance of antibodies to B-lymphocyte (DRw) alloantigens of the kidney donor was significantly associated with the rejection of the graft within 1 month of transplantation or the poor recovery of graft function, despite treatment for rejection. None of the 10 recipients whose grafts were accepted or whose renal function recovered well after treatment for rejection made antibodies to donor B-lymphocyte antigens after transplantation. DRw antigens are thus targets for the host's immune response to a graft and may be responsible for kidney rejection in patients who do not respond to rejection therapy.
在18例肾移植受者中，肾移植后出现针对供体肾B淋巴细胞（DRw）同种异体抗原的抗体，与移植后1个月内移植肾排斥反应或移植肾功能恢复不良显著相关，尽管已进行抗排斥治疗。在10例移植肾被接受或抗排斥治疗后肾功能恢复良好的受者中，无一例在移植后产生针对供体B淋巴细胞抗原的抗体。因此，DRw抗原是宿主对移植肾免疫反应的靶标，可能是对抗排斥治疗无反应患者肾排斥反应的原因。
