Ettenger R B, Terasaki P I, Ting A, Malekzadeh M H, Pennisi A J, Uittenbogaart C, Garrison R, Fine R N
N Engl J Med. 1976 Aug 5;295(6):305-9. doi: 10.1056/NEJM197608052950603.
To determine the possible role of the B lymphocyte alloantigen system in renal-transplant rejection, we examined serum specimens from 81 allograft recipients for cytotoxic activity against a panel of normal B lymphocytes. Specimens from 22 of 25 recipients undergoing allograft rejection demonstrated strong B-lymphocyte cytotoxicity whereas only 13 of 56 recipients with normal allograft function showed similar B lymphocyte cytotoxocitiy (P less than 0.0001). In the serum samples of recipients with graft rejection who were followed sequentially, B-lymphocyte cytotoxicity preceded or was concurrent with the onset of functional impairment. The results show that anti-B-lymphocyte antibodies are associated with rejection, but it is quite possible that they are the products of rejection rather than the cause.
为了确定B淋巴细胞同种抗原系统在肾移植排斥反应中可能发挥的作用，我们检测了81例同种异体肾移植受者血清标本对一组正常B淋巴细胞的细胞毒活性。25例发生移植排斥反应的受者中，有22例的标本表现出强烈的B淋巴细胞细胞毒性，而56例移植肾功能正常的受者中只有13例表现出类似的B淋巴细胞细胞毒性（P<0.0001）。在随访的发生移植排斥反应的受者血清样本中，B淋巴细胞细胞毒性在功能损害发生之前或与之同时出现。结果表明，抗B淋巴细胞抗体与排斥反应有关，但它们很可能是排斥反应的产物而非原因。
