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多种多硫酸化碳水化合物对硫酸乙酰肝素及其他糖胺聚糖与幽门螺杆菌结合的抑制作用

Inhibition of heparan sulphate and other glycosaminoglycans binding to Helicobacter pylori by various polysulphated carbohydrates.

作者信息

Hirmo S, Utt M, Ringner M, Wadström T

机构信息

University of Lund, Institute of Medical Microbiology, Sweden.

出版信息

FEMS Immunol Med Microbiol. 1995 Feb;10(3-4):301-6. doi: 10.1111/j.1574-695X.1995.tb00048.x.

DOI:10.1111/j.1574-695X.1995.tb00048.x
PMID:7539671
Abstract

Heparan sulphate binding to Helicobacter pylori at pH 4 to 5 was inhibited with various sulphated polysaccharides (heparin and chondroitin sulphates, fucoidan, carrageenans and some others), but not by carboxylated or nonsulphated compounds. Heparin binding proteins are exposed on the cell surface.

摘要

在pH 4至5的条件下，硫酸乙酰肝素与幽门螺杆菌的结合受到多种硫酸化多糖（肝素、硫酸软骨素、岩藻依聚糖、角叉菜胶等）的抑制，但不受羧化或非硫酸化化合物的抑制。肝素结合蛋白暴露于细胞表面。

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