Helliwell T R, King A P, Raraty M, Wittram C, Morris A I, Myint S, Hershman M J
Department of Pathology, University of Liverpool, United Kingdom.
Cancer. 1995 Jun 15;75(12):2862-6. doi: 10.1002/1097-0142(19950615)75:12<2862::aid-cncr2820751211>3.0.co;2-q.
A 46-year-old man presented with recurrent anemia and polyarthralgia. Investigations revealed a mass in the ileal mesentery, which was resected. Results of routine histologic examination suggested a diagnosis of synovial sarcoma, a rare malignancy usually not reported at this site.
Tissue was examined immunohistochemically, ultrastructurally, and by fluorescent in situ hybridization to confirm the diagnosis.
Immunohistochemical studies revealed widespread labeling for cytokeratins and focal labeling for desmin and vimentin in the epithelial component, with labeling for epithelial membrane antigen in the epithelial and spindle-cell components. Fluorescent in situ hybridization analysis showed the characteristic t(X;18) translocation of synovial sarcoma.
This is a unique case of synovial sarcoma in the small intestinal mesentery. Immunohistochemical labeling confirmed the diagnosis, although, to the authors' knowledge, the pattern of desmin labeling has not been described previously. The clinical association with polyarthralgia, which resolved after removal of the neoplasm, also has not been described previously.
一名46岁男性出现反复贫血和多关节痛。检查发现回肠系膜有一肿块，遂将其切除。常规组织学检查结果提示为滑膜肉瘤，这是一种罕见的恶性肿瘤，通常不在该部位报道。
对组织进行免疫组织化学、超微结构及荧光原位杂交检查以确诊。
免疫组织化学研究显示，上皮成分中细胞角蛋白广泛标记，结蛋白和波形蛋白局灶性标记，上皮和梭形细胞成分中均有上皮膜抗原标记。荧光原位杂交分析显示滑膜肉瘤特征性的t(X;18)易位。
这是一例发生于小肠系膜的独特滑膜肉瘤病例。免疫组织化学标记确诊了该病，尽管据作者所知，结蛋白标记模式此前尚未见描述。肿瘤切除后多关节痛缓解，这种临床关联此前也未被描述过。
