Olsson T
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Neurology. 1995 Jun;45(6 Suppl 6):S11-5. doi: 10.1212/wnl.45.6_suppl_6.s11.
In both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis, the regulation of the cytokine spectrum and production is likely to have a decisive influence on disease outcome. Studies of cytokines, however, are hampered by the autocrine or paracrine nature of cytokines. Studies of cellular production by messenger RNA detection or cellular secretion are therefore necessary. Collective data suggest that certain cytokines associated with the TH1 phenotype or lymphocytes, such as tumor necrosis factor alpha, lymphotoxin, interleukin-12, and interferon gamma, may promote disease, while cytokines produced by the TH2 subset, such as interleukin-10, may limit disease. In addition, transforming growth factor beta is a putative disease downregulator. Increased knowledge in this field will likely lead to improved therapy for MS patients.
在多发性硬化症（MS）和实验性自身免疫性脑脊髓炎中，细胞因子谱及其产生的调节可能对疾病转归具有决定性影响。然而，细胞因子的自分泌或旁分泌特性阻碍了对其的研究。因此，有必要通过信使核糖核酸检测或细胞分泌来研究细胞产生情况。汇总数据表明，某些与TH1表型或淋巴细胞相关的细胞因子，如肿瘤坏死因子α、淋巴毒素、白细胞介素-12和干扰素γ，可能会促进疾病发展，而TH2亚群产生的细胞因子，如白细胞介素-10，则可能会限制疾病发展。此外，转化生长因子β被认为是一种疾病下调因子。该领域知识的增加可能会为MS患者带来更好的治疗方法。
