Kok Yung-Yean, Ong Hing-Huat, Say Yee-How
Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia.
J Obes. 2017;2017:4104137. doi: 10.1155/2017/4104137. Epub 2017 Feb 15.
Interleukin-1 receptor antagonist () intron 2 86 bp repeat and interleukin-4 () intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of and VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of and were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals with I/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79; = 0.002); II allele = 5.78 (CI = 1.73, 19.29; = 0.004)]. However, VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23; = 0.03)]. Individuals with II allele had significantly higher TBF than those with I allele (31.79 ± 2.52 23.51 ± 0.40; = 0.005). Taken together, intron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.
白细胞介素-1受体拮抗剂（）内含子2 86bp重复序列和白细胞介素-4（）内含子3 70bp重复序列是可变数目串联重复序列（VNTRs），它们与多种疾病相关，但其在肥胖症中的作用尚不清楚。本研究的目的是调查315名马来西亚受试者（128名男性/187名女性；23名马来人/251名华裔/41名印度裔）中与肥胖症和肥胖程度的关联。和的等位基因分布在不同种族之间存在显著差异，且这些等位基因与全身脂肪（TBF）类别相关。即使在控制种族因素后，与具有I/I基因型或I等位基因的个体相比，具有I/II基因型或II等位基因的个体分别有更高的总体肥胖风险[I/II基因型的优势比（OR）=12.21（CI = 2.54，58.79；=0.002）；II等位基因=5.78（CI = 1.73，19.29；=0.004）]。然而，VNTR B2等位基因仅在调整种族因素之前与总体肥胖状态显著相关[OR = 1.53（CI = 1.04，2.23；=0.03）]。具有II等位基因的个体的TBF显著高于具有I等位基因的个体（31.79±2.52对23.51±0.40；=0.005）。综上所述，内含子2 VNTR似乎是马来西亚受试者总体肥胖状态的一个遗传标记。
