Mazzocchi G, Malendowicz L K, Belloni A S, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
Peptides. 1995;16(2):351-5. doi: 10.1016/0196-9781(94)00178-2.
Substance P (SP) increased aldosterone secretion of rat adrenal slices, but not of isolated zona glomerulosa cells, and this effect was annulled by two specific antagonist of SP (SP-A). Both tissue preparations displayed an aldosterone secretory response to isoprenaline (IP) that was blocked by l-alprenolol (AL). AL reversed the aldosterone response of adrenal slices to IP, SP, or IP plus SP, whereas SP-A only suppressed that to SP. Quarters of adrenocortical autotransplants, which are completely deprived of chromaffin cells, showed an aldosterone response to IP, but not to SP. These findings suggest that the mechanism underlying the aldosterone secretagogue action of SP probably involves the stimulation of catecholamine release by adrenal medulla chromaffin cells.
P物质（SP）可增加大鼠肾上腺切片的醛固酮分泌，但对分离的球状带细胞无此作用，且该作用被两种SP特异性拮抗剂（SP-A）消除。两种组织制剂对异丙肾上腺素（IP）均表现出醛固酮分泌反应，该反应被左旋阿普洛尔（AL）阻断。AL可逆转肾上腺切片对IP、SP或IP加SP的醛固酮反应，而SP-A仅抑制对SP的反应。完全缺乏嗜铬细胞的肾上腺皮质自体移植四分之一显示对IP有醛固酮反应，但对SP无反应。这些发现表明，SP醛固酮促分泌作用的潜在机制可能涉及肾上腺髓质嗜铬细胞对儿茶酚胺释放的刺激。
