自身免疫性副肿瘤性小脑变性：抗体结合位点的免疫组织学定位
Autoimmune paraneoplastic cerebellar degeneration: immunohistological localization of antibody-binding sites.
作者信息
Nardelli E, Currò-Dossi B, Rizzuto N, Graus F
机构信息
Dipartimento di Scienze Neurologiche e della Visione, Policlinico Borgo Roma, Università degli Studi di Verona, Italy.
出版信息
Clin Neurol Neurosurg. 1995 Feb;97(1):89-94. doi: 10.1016/0303-8467(95)00004-4.
Sera from 3 patients with breast or ovarian tumors and paraneoplastic cerebellar degeneration (PCD) contained anti-Purkinje cell antibodies (PCAbs) which also bind to other neurons on frozen sections of adult rodent brain. PCAbs tested on new-born rodent (rabbit, rat, mouse) brain tissue detected only oligodendrocyte-like cells (ODLC) in the white matter and allowed us to speculate on the nature of the antigenic structure in the neuronal cytoplasm. All these PCAbs appear histochemically identical and recognize antigens which belong to so-called "Yo" proteins.
来自3例患有乳腺或卵巢肿瘤及副肿瘤性小脑变性（PCD）患者的血清中含有抗浦肯野细胞抗体（PCAbs），这些抗体在成年啮齿动物脑冰冻切片上也能与其他神经元结合。在新生啮齿动物（兔、大鼠、小鼠）脑组织上检测的PCAbs仅在白质中检测到少突胶质细胞样细胞（ODLC），这使我们能够推测神经元细胞质中抗原结构的性质。所有这些PCAbs在组织化学上看起来相同，并识别属于所谓“Yo”蛋白的抗原。
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