自身免疫性副肿瘤性小脑变性：抗体结合位点的免疫组织学定位

Autoimmune paraneoplastic cerebellar degeneration: immunohistological localization of antibody-binding sites.

作者信息

Nardelli E, Currò-Dossi B, Rizzuto N, Graus F

机构信息

Dipartimento di Scienze Neurologiche e della Visione, Policlinico Borgo Roma, Università degli Studi di Verona, Italy.

出版信息

Clin Neurol Neurosurg. 1995 Feb;97(1):89-94. doi: 10.1016/0303-8467(95)00004-4.

DOI:10.1016/0303-8467(95)00004-4

Abstract

Sera from 3 patients with breast or ovarian tumors and paraneoplastic cerebellar degeneration (PCD) contained anti-Purkinje cell antibodies (PCAbs) which also bind to other neurons on frozen sections of adult rodent brain. PCAbs tested on new-born rodent (rabbit, rat, mouse) brain tissue detected only oligodendrocyte-like cells (ODLC) in the white matter and allowed us to speculate on the nature of the antigenic structure in the neuronal cytoplasm. All these PCAbs appear histochemically identical and recognize antigens which belong to so-called "Yo" proteins.

摘要

来自3例患有乳腺或卵巢肿瘤及副肿瘤性小脑变性（PCD）患者的血清中含有抗浦肯野细胞抗体（PCAbs），这些抗体在成年啮齿动物脑冰冻切片上也能与其他神经元结合。在新生啮齿动物（兔、大鼠、小鼠）脑组织上检测的PCAbs仅在白质中检测到少突胶质细胞样细胞（ODLC），这使我们能够推测神经元细胞质中抗原结构的性质。所有这些PCAbs在组织化学上看起来相同，并识别属于所谓“Yo”蛋白的抗原。

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1

Autoimmune paraneoplastic cerebellar degeneration: immunohistological localization of antibody-binding sites.自身免疫性副肿瘤性小脑变性：抗体结合位点的免疫组织学定位

Clin Neurol Neurosurg. 1995 Feb;97(1):89-94. doi: 10.1016/0303-8467(95)00004-4.

2

Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice.建立抗Yo抗体介导的副肿瘤性小脑变性动物模型的试验。2. 将用重组Yo蛋白激活的小鼠单核细胞被动转移至重度联合免疫缺陷小鼠的副肿瘤性小脑变性淋巴细胞中。

Clin Neurol Neurosurg. 1995 Feb;97(1):101-5. doi: 10.1016/0303-8467(95)00006-6.

3

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4

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5

[Paraneoplastic cerebellar degeneration associated with ovarian cancer: anti-Yo immunoreactivity in autoptic cerebellum and ovarian carcinoma].[与卵巢癌相关的副肿瘤性小脑变性：尸检小脑和卵巢癌中的抗Yo免疫反应性]

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Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen.副肿瘤性小脑变性患者对浦肯野细胞胞质蛋白抗原的自身免疫反应。

Ann Neurol. 1985 Nov;18(5):592-600. doi: 10.1002/ana.410180513.

8

[Paraneoplastic cerebellar degeneration (PCD) with anti-Yo antibodies in ovarian carcinoma].卵巢癌伴抗Yo抗体的副肿瘤性小脑变性（PCD）

Schweiz Med Wochenschr. 1998 Jun 6;128(23):906-8.

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[Paraneoplastic cerebellar degeneration--characterization of anti-Yo antibody and underlying cancer].[副肿瘤性小脑变性——抗Yo抗体及潜在癌症的特征]

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