法国南部与类风湿关节炎相关的HLA - DRB1等位基因。尽管存在共享表位的表达，但无关节外疾病。
HLA-DRB1 alleles associated with rheumatoid arthritis in southern France. Absence of extraarticular disease despite expression of the shared epitope.
作者信息
Benazet J F, Reviron D, Mercier P, Roux H, Roudier J
机构信息
Immuno Rheumatology Laboratory, Faculté de Médecine, Hôpital La Conception, Marseille, France.
出版信息
J Rheumatol. 1995 Apr;22(4):607-10.
OBJECTIVE
Extraarticular rheumatoid arthritis (RA) is almost unknown in Marseille in southern France. We investigated whether this was due to rare expression of the HLA-DRB1 shared epitope.
METHODS
HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization.
RESULTS
In patients with RA, 76% expressed the shared epitope (46% DR1, 45% DR4). Four HLA-DRB1 alleles were positively associated with disease: DRB10101, DRB10401, DRB10404, DRB10405. Patients with double dose shared epitope had the most severe articular damage, but no extraarticular disease.
CONCLUSION
In Marseille, 76% of patients with RA are shared epitope positive. Still, most do not develop extraarticular RA. This may be caused by the low frequency of HLA-DRB1*0401 in this population.
目的
法国南部马赛地区几乎不存在关节外类风湿性关节炎（RA）。我们调查了这是否是由于HLA - DRB1共享表位的罕见表达所致。
方法
通过聚合酶链反应扩增和寡核苷酸杂交对73例RA患者和108名对照者的HLA - DRB1等位基因进行特征分析。
结果
在RA患者中，76%表达共享表位（46%为DR1，45%为DR4）。四个HLA - DRB1等位基因与疾病呈正相关：DRB10101、DRB10401、DRB10404、DRB10405。具有双剂量共享表位的患者关节损伤最严重，但无关节外疾病。
结论
在马赛，76%的RA患者共享表位呈阳性。然而，大多数患者并未发展为关节外RA。这可能是由于该人群中HLA - DRB1*0401的频率较低所致。
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