Dudek R, Wildhirt S, Suzuki H, Winder S, Bing R J
Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA 91101, USA.
Pharmacology. 1995 Apr;50(4):257-60. doi: 10.1159/000139290.
The amphiphile lysophosphatidylcholine (LPC) modulates the activity of membrane-associated enzymes such as phospholipase A2, adenylate and guanylate cyclases and ATPase. LPC also relaxes vascular smooth muscle through production of nitric oxide. On the basis of reports that bradykinin translocates nitric oxide synthase (NOS) from the membrane to the cytosol, we investigated whether a similar translocation occurs with LPC. It was found that LPC translocated NOS from the membrane to the cytosolic fraction. Total NOS activity remained at the control level.
两亲性溶血磷脂酰胆碱（LPC）可调节膜相关酶的活性，如磷脂酶A2、腺苷酸环化酶、鸟苷酸环化酶和ATP酶。LPC还通过产生一氧化氮使血管平滑肌舒张。基于缓激肽可使一氧化氮合酶（NOS）从膜转位至胞质溶胶的报道，我们研究了LPC是否会发生类似的转位。结果发现，LPC可使NOS从膜转位至胞质组分。总NOS活性维持在对照水平。
