Honoré N, Marchal G, Cole S T
Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris, France.
Antimicrob Agents Chemother. 1995 Mar;39(3):769-70. doi: 10.1128/AAC.39.3.769.
Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.
结核分枝杆菌链霉素依赖突变体的分子特征揭示,在编码16S rRNA的rrs基因中存在一个新突变。在16S rRNA的530环中额外插入一个胞嘧啶,该区域已知与链霉素敏感性和耐药性有关,这与链霉素依赖相关。