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腹腔镜胆道和胃旁路手术:治疗胰腺癌的一种有用辅助手段。

Laparoscopic biliary and gastric bypass: a useful adjunct in the treatment of carcinoma of the pancreas.

作者信息

Rhodes M, Nathanson L, Fielding G

机构信息

University Department of Surgery, Royal Brisbane Hospital, Australia.

出版信息

Gut. 1995 May;36(5):778-80. doi: 10.1136/gut.36.5.778.

Abstract

Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. Laparoscopic biliary and gastric bypass offers a less invasive alternative than open surgery with shorter hospital stay and more rapid return to normal activity. Between August 1991 and March 1994, 16 patients (median age 69 years, range 31-85) had laparoscopic bypass surgery. The indications for surgery were gastric outlet obstruction at initial presentation (n = 4), blocked biliary stent (n = 8), and metastatic tumour at laparoscopy (n = 4). Surgery took the form of cholecystjejunostomy (n = 7), gastroenterostomy (n = 5), both procedures (n = 3), and failed operation (n = 1). Operative duration was 75 minutes (range 45-190) and hospital stay four days (range 3-33) and all apart from two patients were discharged from hospital in seven days or less. Morbidity occurred in two patients (13%) in the form of a cerebrovascular accident and delayed gastric emptying. Median survival in 10 patients who have died is 201 days (range 20-525). Laparoscopic biliary and gastric bypass is possible in most patients in whom endoscopic stenting has failed and in those who subsequently develop gastric outlet obstruction. Hospital stay is shorter than after open surgery and recovery more rapid.

摘要

超过90%的无法手术切除的胰腺癌患者通过内镜逆行胰胆管造影术和支架置入术成功缓解症状。对于剩余10%的患者进行治疗通常需要开腹手术,但鉴于这些患者的中位生存期仅为150天,这种手术很难说得过去。腹腔镜下胆肠和胃肠吻合术提供了一种比开放手术侵入性更小的选择,住院时间更短,恢复正常活动更快。在1991年8月至1994年3月期间,16例患者(中位年龄69岁,范围31 - 85岁)接受了腹腔镜下旁路手术。手术指征为初次就诊时胃出口梗阻(4例)、胆管支架堵塞(8例)以及腹腔镜检查时发现转移瘤(4例)。手术方式包括胆囊空肠吻合术(7例)、胃肠吻合术(5例)、两种手术均施行(3例)以及手术失败(1例)。手术持续时间为75分钟(范围45 - 190分钟),住院时间为4天(范围3 - 33天),除2例患者外,所有患者均在7天或更短时间内出院。2例患者(13%)出现并发症,分别为脑血管意外和胃排空延迟。10例死亡患者的中位生存期为201天(范围20 - 525天)。对于大多数内镜支架置入失败以及随后出现胃出口梗阻的患者,腹腔镜下胆肠和胃肠吻合术是可行的。其住院时间比开放手术后短,恢复更快。

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