Cameron C M, Engelbrecht M M, Vermeulen A S
Onderstepoort J Vet Res. 1978 Dec;45(4):215-20.
Investigations with antisera prepared in rabbits and sheep and active immunity experiments in mice showed that strains of Pasteurella multocida which, according to the haemagglutination test, are serologically related, do not necessarily give rise to cross immunity. Conversely, it was found that serologically unrelated strains may exhibit an appreciable degree of cross protection. The unreliability of the haemagglutination test as an indicator of immunological identity of strains was further confirmed in that peritoneal fluid from immunized mice showed passive protection properties despite the absence of haemagglutinating antibodies. There was no consistent agreement between the results obtained with antisera prepared in different species and active immunity experiments in mice, and this leads to the conclusion that different species probably vary quantitatively and qualitatively in their immune response to immunization with P. multocida. Attempts to determine whether combined bacterins afforded a better immunity than monovalent bacterins were inconclusive.
用兔和羊制备的抗血清进行的研究以及在小鼠身上进行的主动免疫实验表明，根据血凝试验在血清学上相关的多杀巴斯德菌菌株，不一定会产生交叉免疫。相反，发现血清学不相关的菌株可能表现出相当程度的交叉保护。免疫小鼠的腹腔液尽管没有血凝抗体，但仍表现出被动保护特性，这进一步证实了血凝试验作为菌株免疫同一性指标的不可靠性。用不同物种制备的抗血清所获得的结果与在小鼠身上进行的主动免疫实验结果之间没有一致的一致性，这导致得出结论，不同物种对多杀巴斯德菌免疫接种的免疫反应可能在数量和质量上有所不同。试图确定联合菌苗是否比单价菌苗提供更好的免疫力的尝试没有得出结论。
