血清睾酮在正常范围内的生理变化不会影响血清前列腺特异性抗原。
Physiologic variations of serum testosterone within the normal range do not affect serum prostate-specific antigen.
作者信息
Monath J R, McCullough D L, Hart L J, Jarow J P
机构信息
Department of Urology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
出版信息
Urology. 1995 Jul;46(1):58-61. doi: 10.1016/S0090-4295(99)80159-9.
OBJECTIVES
To determine the relationship between endogenous total serum testosterone levels and serum prostate-specific antigen (PSA) concentrations. If a correlation exists between these two parameters, then use of testosterone-specific reference ranges may enhance the utility of PSA as a marker for prostate cancer.
METHODS
Data were obtained from 150 men without previous history of prostate cancer. PSA was measured by the Abbott IMX microparticle enzyme immunoassay and total testosterone determined by the Coat-A-Count radioimmunoassay.
RESULTS
No correlation was found between testosterone and PSA, even when corrected for age and weight.
CONCLUSIONS
The data suggest that determination of the total serum testosterone level does not improve the sensitivity or specificity of PSA as a tumor marker.
目的
确定内源性血清总睾酮水平与血清前列腺特异性抗原（PSA）浓度之间的关系。如果这两个参数之间存在相关性，那么使用睾酮特异性参考范围可能会提高PSA作为前列腺癌标志物的效用。
方法
数据来自150名无前列腺癌病史的男性。PSA采用雅培IMX微粒酶免疫分析法测定，总睾酮采用Coat-A-Count放射免疫分析法测定。
结果
即使校正了年龄和体重，睾酮与PSA之间也未发现相关性。
结论
数据表明，测定血清总睾酮水平并不能提高PSA作为肿瘤标志物的敏感性或特异性。
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