Miller W, Butters M, Bittner R
Chirurgische Klinik, Marienhospitals Stuttgart.
Chirurg. 1995 May;66(5):541-4.
A midaged lady suffering from ulcer disease for about seven years had undergone several surgical and drug therapies without any satisfying success. Then the diagnosis of a gastrinoma was made. By this time there were already multiple liver metastases. First the large supposed primary tumor of the pancreas was resected and within six months later the resection of the progressing liver metastases became necessary because of local tumor complications. The additional drug therapy with octreotide (Sandostatin) given three times daily subcutaneously prevented further tumor progress. Until now this combination of surgical and medical treatment has proved to be a successful palliative method of treating the malignant gastrinoma for 2.5 years.
一位患有溃疡病约七年的中年女性接受了多种手术和药物治疗，但均未取得满意疗效。随后确诊为胃泌素瘤。此时已有多处肝转移。首先切除了胰腺上假定的大的原发肿瘤，六个月后，由于局部肿瘤并发症，有必要切除进展性肝转移灶。每天皮下注射三次奥曲肽（善宁）的辅助药物治疗阻止了肿瘤的进一步进展。到目前为止，这种手术和药物联合治疗已被证明是一种成功的姑息治疗方法，治疗恶性胃泌素瘤达2.5年。
