Abood Gerard J, Go Aileen, Malhotra Deepak, Shoup Margo
Department of General Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
Surg Clin North Am. 2009 Feb;89(1):249-66, x. doi: 10.1016/j.suc.2008.10.001.
Neuroendocrine tumors of the pancreas comprise a class of rare tumors that can be associated with symptoms of hormone overproduction. Five distinct clinical endocrinopathies are associated with neuroendocrine tumors; however, most of these tumors remain asymptomatic and follow an indolent course. Complete surgical resection offers the only hope for cure, but understanding the basic biology of the tumors has advanced the medical management in metastatic disease. Surgical resection of hepatic metastases offers survival advantage and should be performed when feasible. Although hepatic artery embolization is currently the preferred mode of nonsurgical palliation for pain and hormonal symptoms, other modalities may play a role in metastatic disease.
胰腺神经内分泌肿瘤是一类罕见肿瘤，可伴有激素过度分泌症状。五种不同的临床内分泌病与神经内分泌肿瘤相关；然而，这些肿瘤大多无症状，病程进展缓慢。完整的手术切除是治愈的唯一希望，但对肿瘤基本生物学的了解推动了转移性疾病的医学管理。肝转移瘤的手术切除可带来生存优势，可行时应进行手术。虽然肝动脉栓塞目前是缓解疼痛和激素症状的非手术姑息治疗的首选方式，但其他方法在转移性疾病中可能也发挥作用。
