载脂蛋白-D和前列腺特异性抗原在前列腺良性和恶性组织中的差异表达。
Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues.
作者信息
Aspinall J O, Bentel J M, Horsfall D J, Haagensen D E, Marshall V R, Tilley W D
机构信息
Department of Surgery, School of Medicine, Flinders University of South Australia, Bedford Park.
出版信息
J Urol. 1995 Aug;154(2 Pt 1):622-8. doi: 10.1097/00005392-199508000-00082.
PURPOSE
To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues.
MATERIALS AND METHODS
Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D2 prostate cancers.
RESULTS
Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p < 0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates.
CONCLUSIONS
Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.
目的
研究载脂蛋白-D（Apo-D）和前列腺特异性抗原（PSA）在人前列腺非恶性和恶性组织中的免疫组织化学染色情况。
材料与方法
通过视频图像分析评估载脂蛋白-D和PSA在非恶性前列腺组织及30例D2期前列腺癌中的免疫反应性。
结果
在所有30个肿瘤中均检测到载脂蛋白-D，与年龄匹配的非恶性前列腺组织相比，染色水平升高（p < 0.05）。相比之下，肿瘤中PSA染色水平低于非恶性前列腺组织中的检测水平。
结论
载脂蛋白-D在正常人类前列腺中表达。Apo-D染色升高与晚期前列腺癌相关。
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