Suzuki K, Ito K, Ichinose Y, Kurokawa K, Suzuki T, Imai K, Yamanaka H, Honma S
Department of Urology, School of Medicine, Gunma University, Japan.
Scand J Urol Nephrol. 1995 Mar;29(1):65-8. doi: 10.3109/00365599509180541.
Estrogen plays an important role in the development of benign prostatic hyperplasia (BPH), as has been shown in both experimental and clinical studies. T determine the endocrine environment of BPH, serum total testosterone (Total-T), free testosterone (Free-T), and estradiol (E2) conceptions were measured, and the relationship between these levels and prostate size and volume was analyzed. Blood samples were collected from subjects who attended the mass screening for prostate disease performed by our institute. No significant correlations were found between Total-T levels, Free-T levels, and prostate size, as determined by digital rectal examination. However, E2 levels and the ratios for E2 levels and the ratios for E2/Total-T and E2/Free-T were significantly correlated with prostate size. To confirm these relationships, prostate volume was calculated from transrectal ultrasonographic images. E2 levels and these two ratios were, indeed, highly correlated with prostate volume. These results suggest that an estrogen-dominant environment plays an important role in the development of BPH.
正如实验研究和临床研究所显示的那样，雌激素在良性前列腺增生（BPH）的发展过程中起着重要作用。为了确定BPH的内分泌环境，我们测量了血清总睾酮（Total-T）、游离睾酮（Free-T）和雌二醇（E2）的含量，并分析了这些水平与前列腺大小和体积之间的关系。血液样本采集自参加我院前列腺疾病大规模筛查的受试者。通过直肠指检确定，Total-T水平、Free-T水平与前列腺大小之间未发现显著相关性。然而，E2水平以及E2水平的比值、E2/Total-T和E2/Free-T的比值与前列腺大小显著相关。为了证实这些关系，我们通过经直肠超声图像计算前列腺体积。事实上，E2水平以及这两个比值与前列腺体积高度相关。这些结果表明，雌激素占主导的环境在BPH的发展中起着重要作用。
