Pedersen J F, Sørensen S, Ruge S
Ultrasound Laboratory, Glostrup Hospital, Denmark.
Acta Obstet Gynecol Scand. 1995 Aug;74(7):505-8. doi: 10.3109/00016349509024379.
To study in an optimized design the possible relation between serum levels in weeks 8-14 of human placental lactogen and pregnancy-associated plasma protein A and fetal size at delivery.
Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human placental lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth.
Serum levels of human placental lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p < 0.01 and p < 0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p < 0.02).
Higher levels of human placental lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe because of better fetal growth, and higher levels of pregnancy-associated plasma protein A predicted better fetal growth.
采用优化设计研究孕8至14周时血清人胎盘催乳素和妊娠相关血浆蛋白A水平与分娩时胎儿大小之间的可能关系。
分析93例正常单胎妊娠的数据。通过超声测量头臀长度评估孕周。采用放射免疫分析法测定血清人胎盘催乳素和妊娠相关血浆蛋白A水平，并以均值倍数表示。相对出生体重用作胎儿生长指标。
血清人胎盘催乳素和妊娠相关血浆蛋白A水平与分娩时孕周呈负相关（分别为p < 0.01和p < 0.05），且妊娠相关血浆蛋白A血清水平与相对出生体重呈正相关（p < 0.02）。
较高水平的人胎盘催乳素和妊娠相关血浆蛋白A预示着较早分娩，可能是因为胎儿生长较好，且较高水平的妊娠相关血浆蛋白A预示着胎儿生长较好。
