Whitfield C
Dept of Microbiology, University of Guelph, Ontario, Canada.
Trends Microbiol. 1995 May;3(5):178-85. doi: 10.1016/s0966-842x(00)88917-9.
Lipopolysaccharide O antigens are important virulence determinants for many bacteria. O-antigen synthesis is an interesting problem in cell-surface assembly. There are two known assembly pathways, which differ in the cellular location of their polymerization steps and in the direction of chain polymerization. Some reactions are shared with those for other surface polymers, such as capsular polysaccharides, and may be potential targets for therapeutic intervention.
脂多糖O抗原是许多细菌重要的毒力决定因素。O抗原合成是细胞表面组装过程中一个有趣的问题。已知有两条组装途径，它们在聚合步骤的细胞定位以及链聚合方向上有所不同。一些反应与其他表面聚合物（如荚膜多糖）的反应相同，可能是治疗干预的潜在靶点。
