Dordunoo S K, Jackson J K, Arsenault L A, Oktaba A M, Hunter W L, Burt H M
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Cancer Chemother Pharmacol. 1995;36(4):279-82. doi: 10.1007/BF00689043.
Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.
