Tan J, Gerrits N M, Nanhoe R, Simpson J I, Voogd J
Department of Anatomy, Erasmus University Rotterdam, The Netherlands.
J Comp Neurol. 1995 May 22;356(1):23-50. doi: 10.1002/cne.903560103.
The localization and termination of olivocerebellar fibers in the flocculus and nodulus of the rabbit were studied with anterograde axonal transport methods [wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) and tritiated leucine] and correlated with the compartments in the white matter of these lobules delineated with acetylcholinesterase histochemistry (Tan et al. J. Comp. Neurol., 1995, this issue). Olivocerebellar fibers originating from the caudal dorsal cap travel through floccular compartments FC2 and FC4 to terminate as climbing fibers in floccular zones FZII and FZIV. Fibers from the rostral dorsal cap and the ventrolateral outgrowth traverse compartments FC1 and FC3, which are interleaved with compartments FC2 and FC4, and terminate in zones FZI and FZIII. Fibers from the rostral pole of the medial accessory olive traverse the C2 compartment and terminate in the C2 zone. FZI-III extend into the adjoining folium (folium p) of the ventral paraflocculus. The C2 zone continues across folium p into other folia of the ventral paraflocculus and into the dorsal paraflocculus. Four compartments and five zones were distinguished in the nodulus. Medial compartment XC1 contains olivocerebellar fibers from the caudal dorsal cap and subnucleus beta that terminate in the XZI zone. Olivocerebellar fibers from the rostral dorsal cap and the ventrolateral outgrowth occupy XC2 and terminate in XZII. The XC4 compartment contains fibers from both the caudal dorsal cap and from the rostral dorsal cap and the ventrolateral outgrowth. The latter terminate in a central portion of the XZIV zone. The dorsomedial cell column projects to the XZIII zone, which is present only in the dorsal part of the nodulus. The rostral medial accessory olive projects to the XZV zone, which occupies the lateral border of the nodulus. These results confirm and extend the conclusions of Katayama and Nisimaru ([1988] Neurosci. Res. 5:424-438) on the zonal pattern in the olivo-nodular projection in the rabbit. Additional observations were made on the presence of a lateral A zone (Buisseret-Delmas [1988] Neurosci. Res. 5:475-493) in the hemisphere of lobules VI and VII. Retrograde labeling of the nucleo-olivary tract of Legendre and Courville ([1987] Neuroscience 21:877-891) was observed after WGA-HRP injections into the inferior olive including the rostral dorsal cap and the ventrolateral outgrowth. The anatomical and functional implications of these observations are discussed.
采用顺行轴突运输方法[麦胚凝集素-辣根过氧化物酶（WGA-HRP）和氚标记亮氨酸]研究了家兔绒球和小结中橄榄小脑纤维的定位和终止情况，并与用乙酰胆碱酯酶组织化学法描绘的这些小叶白质中的分区进行了关联（Tan等人，《比较神经学杂志》，1995年，本期）。源自尾侧背帽的橄榄小脑纤维穿过绒球分区FC2和FC4，作为攀缘纤维终止于绒球区FZII和FZIV。来自吻侧背帽和腹外侧突出部的纤维穿过分区FC1和FC3，它们与分区FC2和FC4交错，并终止于FZI和FZIII区。来自内侧副橄榄吻端的纤维穿过C2分区并终止于C2区。FZI-III延伸至腹侧旁绒球相邻的小叶（小叶p）。C2区穿过小叶p延续至腹侧旁绒球的其他小叶以及背侧旁绒球。在小结中区分出四个分区和五个区。内侧分区XC1包含来自尾侧背帽和β亚核的橄榄小脑纤维，它们终止于XZI区。来自吻侧背帽和腹外侧突出部的橄榄小脑纤维占据XC2并终止于XZII。XC4分区包含来自尾侧背帽以及吻侧背帽和腹外侧突出部的纤维。后者终止于XZIV区的中央部分。背内侧细胞柱投射至XZIII区,该区仅存在于小结的背侧部分。吻侧内侧副橄榄投射至XZV区，该区占据小结的外侧边界。这些结果证实并扩展了Katayama和Nisimaru（[1988]《神经科学研究》5:424 - 438）关于家兔橄榄-小结投射带状模式的结论。另外还观察了小叶VI和VII半球中外侧A区（Buisseret-Delmas [1988]《神经科学研究》5:475 - 493）的存在情况。在将WGA-HRP注射入包括吻侧背帽和腹外侧突出部的下橄榄后，观察到了Legendre和Courville（[1987]《神经科学》21:877 - 891）的核橄榄束的逆行标记。讨论了这些观察结果的解剖学和功能学意义。
