Ng H K
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.
Acta Cytol. 1998 May-Jun;42(3):614-8. doi: 10.1159/000331816.
To review the cytomorphologic picture of pituitary adenomas as revealed by intraoperative smear preparation and to note features useful in differential diagnosis from other sellar tumors.
A total of 46 pituitary adenomas in which intraoperative smears were available were reviewed. All tumors were subsequently examined by paraffin section and immunohistochemistry.
The important cytologic appearances were epithelial cords and sheets with dyscohesive ends, acini and papillary formations. Cytoplasmic contents, depending on functional status, were variably clear, with vacuolation or eosinophilic bodies and occasional paranuclear bodies. Mild cellular pleomorphism and binucleate forms were common.
Pituitary adenomas possess distinct cytologic features that are important in intraoperative differential diagnoses from normal pituitary tissues, germinomas, meningiomas, craniopharyngiomas and oligodendrogliomas.
回顾术中涂片制备所揭示的垂体腺瘤的细胞形态学图像，并记录有助于与其他鞍区肿瘤进行鉴别诊断的特征。
回顾了46例有术中涂片的垂体腺瘤。所有肿瘤随后均通过石蜡切片和免疫组织化学检查。
重要的细胞学表现为上皮条索和细胞松散的片状结构、腺泡和乳头状结构。根据功能状态，细胞质内容物各不相同，有不同程度的清亮、空泡形成或嗜酸性小体，偶尔还有核旁小体。轻度细胞多形性和双核形式很常见。
垂体腺瘤具有独特的细胞学特征，这在术中与正常垂体组织、生殖细胞瘤、脑膜瘤、颅咽管瘤和少突胶质细胞瘤的鉴别诊断中很重要。
