Kurata S, Yamashita U, Nakajima H
Department of Biochemical Genetics, Tokyo Medical and Dental University, Japan.
Biochim Biophys Acta. 1995 Jul 25;1263(1):35-8. doi: 10.1016/0167-4781(95)00084-t.
The effects of hyperbaric oxygenation (HBO) and hyperbaric air (HBA) on the cytostatic activity, peroxynitrite synthesis and transcription of the inducible nitric oxide synthetase (iNOS) gene of murine peritoneal macrophages were studied in vitro. Exposure of mice to HBO or HBA significantly reduced the cytostatic activity, peroxynitrite synthesis and transcription of iNOS mRNA of their macrophages stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). These results indicate that HBO and HBA treatments of mice reduce the cytostatic activity of peritoneal macrophages by reducing iNOS mRNA synthesis.
在体外研究了高压氧（HBO）和高压空气（HBA）对小鼠腹腔巨噬细胞的细胞抑制活性、过氧亚硝酸盐合成及诱导型一氧化氮合酶（iNOS）基因转录的影响。将小鼠暴露于HBO或HBA下，可显著降低其经脂多糖（LPS）和干扰素-γ（IFN-γ）刺激的巨噬细胞的细胞抑制活性、过氧亚硝酸盐合成及iNOS mRNA的转录。这些结果表明，对小鼠进行HBO和HBA处理可通过减少iNOS mRNA合成来降低腹腔巨噬细胞的细胞抑制活性。
