Imai K, Ichinose Y, Kubota Y, Yamanaka H, Sato J
Department of Urology, Gunma University School of Medicine, Japan.
J Urol. 1995 Sep;154(3):1085-9.
The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated.
A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects.
Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity.
The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
研究前列腺特异性抗原（PSA）在前列腺癌大规模筛查中的意义。
对3526名受试者进行了总共4375次PSA、直肠指检和经直肠超声检查。
在这三种检查方式中，PSA具有最高的敏感性（80.4%）和阳性预测值（45.1%）。我们为正常日本男性建立了按年龄划分的PSA参考范围，并证明了PSA密度和PSA速率的意义。
应在多个年龄范围内，并结合既往PSA数据和/或前列腺体积，评估PSA作为前列腺癌筛查方式的意义。
