Yuki N, Ichihashi Y, Taki T
Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
J Neuroimmunol. 1995 Jul;60(1-2):161-4. doi: 10.1016/0165-5728(95)00052-4.
Sera of patients who develop Guillain-Barré syndrome (GBS) subsequent to Campylobacter jejuni enteritis frequently have IgG anti-GM1 antibody. Lipopolysaccharide (LPS) of C. jejuni isolated from a GBS patient has a GM1 ganglioside-like structure. IgG subclass distribution of the anti-GM1 antibody in GBS patients is mainly restricted to IgG1 and IgG3. Since IgG antibodies to bacterial polysaccharide generally are restricted to IgG2 subclass, some investigators have assumed that either the general rules for immune response to LPS are broken in the patients or an alternative antigen has yet to be identified. To clarify whether the LPS participates in the production of the anti-GM1 antibody, we investigated the subclass of IgG antibody to the LPS that bears GM1-like structure. The subclasses of IgG antibody to the LPS were restricted predominantly to IgG1 and IgG3. The GM1 epitope-bearing LPS may function in the production of the anti-GM1 antibody in patients with GBS subsequent to C. jejuni infection.
空肠弯曲菌肠炎后发生吉兰-巴雷综合征（GBS）的患者血清中常含有IgG抗GM1抗体。从一名GBS患者分离出的空肠弯曲菌的脂多糖（LPS）具有GM1神经节苷脂样结构。GBS患者抗GM1抗体的IgG亚类分布主要限于IgG1和IgG3。由于针对细菌多糖的IgG抗体通常限于IgG2亚类，一些研究者推测，要么这些患者对LPS的免疫反应一般规律被打破，要么还有一种替代抗原有待确定。为了阐明LPS是否参与抗GM1抗体的产生，我们研究了针对具有GM1样结构的LPS的IgG抗体亚类。针对LPS的IgG抗体亚类主要限于IgG1和IgG3。携带GM1表位的LPS可能在空肠弯曲菌感染后GBS患者抗GM1抗体的产生中发挥作用。
