Ogino M, Orazio N, Latov N
Department of Neurology, Columbia Presbyterian, Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
J Neuroimmunol. 1995 Apr;58(1):77-80. doi: 10.1016/0165-5728(94)00190-y.
Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.
在一些吉兰-巴雷综合征患者中，尤其是运动轴索性变异型患者，以及空肠弯曲菌感染后或经肠外给予神经节苷脂后，抗GM1和抗唾液酸GM1（GA1）神经节苷脂抗体的滴度会升高。使用针对人IgG亚类的小鼠单克隆抗体，通过酶联免疫吸附测定法（ELISA）检测了19例急性运动神经病且抗体滴度升高患者的抗GM1或GA1抗体的亚类分布。抗GM1或GA1抗体主要为IgG1和IgG3亚类，它们能够固定补体，是T细胞依赖性抗体反应的特征。
