Doi M, Uji Y, Yamamura H
Department of Ophthalmology, School of Medicine, Mie University, Japan.
J Comp Neurol. 1995 Jun 5;356(3):368-86. doi: 10.1002/cne.903560305.
Mice have been used for extensive studies on optic nerves and retinal ganglion cells, but mouse retinal ganglion cells have not been classified morphologically. In the present study, normally placed retinal ganglion cells and displaced retinal ganglion cells in pigmented and albino mice were classified morphologically using horseradish peroxidase. These cells were classified into three types according to the sizes of the soma and the dendritic field: type I cells, large soma and large dendritic field; type II cells, small-to-medium soma and small dendritic field; and type III cells, small-to-medium soma and large dendritic field. Some ganglion cells had both symmetric and asymmetric cells. Each type was further subdivided according to the termination level of dendrites in the inner plexiform layer and the dendritic branching pattern. Except for type III displaced ganglion cells, dendrites of the normally placed ganglion cells and the displaced ganglion cells ramify in the outer two-fifths of the inner plexiform layer (sublamina a) or the inner three-fifths of the inner plexiform layer (sublamina b). Type III displaced ganglion cells ramify only in sublamina a. Dendrites of some normally placed type I ganglion cells ramify in both sublaminae. Displaced biplexiform cells were observed, the dendrites of which ramify in both the inner and the outer plexiform layers. All cell types were found in both mouse strains.
小鼠已被广泛用于视神经和视网膜神经节细胞的研究，但小鼠视网膜神经节细胞尚未进行形态学分类。在本研究中，使用辣根过氧化物酶对有色和白化小鼠中正常位置的视网膜神经节细胞和移位的视网膜神经节细胞进行了形态学分类。这些细胞根据胞体大小和树突野分为三种类型：I型细胞，胞体大且树突野大；II型细胞，胞体小至中等且树突野小；III型细胞，胞体小至中等且树突野大。一些神经节细胞同时具有对称和不对称细胞。每种类型根据树突在内网状层的终止水平和树突分支模式进一步细分。除III型移位神经节细胞外，正常位置的神经节细胞和移位神经节细胞的树突在内网状层的外五分之二（a亚层）或内网状层的内五分之三（b亚层）分支。III型移位神经节细胞仅在a亚层分支。一些正常位置的I型神经节细胞的树突在两个亚层都有分支。观察到移位的双极细胞，其树突在内网状层和外网状层都有分支。两种小鼠品系中均发现了所有细胞类型。
