Ilunga K, Iriyama K
Department of Pathology, Mie University School of Medicine, Tsu, Japan.
Br J Surg. 1995 Jul;82(7):948-51. doi: 10.1002/bjs.1800820730.
Tenascin expression was determined by an immunohistochemical technique in 120 surgical specimens of gastric carcinoma to investigate its relationship with clinicopathological factors. Tenascin expression was more prominent in the neoplastic area than in the adjacent non-neoplastic mucosa. Tenascin was frequently observed in gastric mucosa with diffuse chronic gastritis, glandular atrophy and intestinal metaplasia. In the neoplastic area, tenascin expression was positive in 72 cases (60 per cent). Tumours with a high frequency of tenascin expression included: Borrmann type II (19 of 20), well or moderately differentiated tumours (52 of 63), tumours with expansive growth and with an intermediate growth pattern (40 of 42), and those with a medullary or intermediate-type stroma (55 of 73). There was no significant relationship between tenascin expression and age, sex, depth of tumour invasion, lymph node metastasis, invasion to lymphatic vessel, venous invasion and the 4-year survival rate.
采用免疫组织化学技术检测120例胃癌手术标本中腱生蛋白的表达，以研究其与临床病理因素的关系。腱生蛋白在肿瘤区域的表达比在邻近的非肿瘤黏膜中更显著。在伴有弥漫性慢性胃炎、腺体萎缩和肠化生的胃黏膜中经常观察到腱生蛋白。在肿瘤区域，72例（60%）腱生蛋白表达呈阳性。腱生蛋白高表达的肿瘤包括：BorrmannⅡ型（20例中的19例）、高分化或中分化肿瘤（63例中的52例）、呈膨胀性生长和中间生长模式的肿瘤（42例中的40例）以及具有髓样或中间型基质的肿瘤（73例中的55例）。腱生蛋白表达与年龄、性别、肿瘤浸润深度、淋巴结转移、淋巴管浸润、静脉浸润及4年生存率之间无显著关系。
