Ikeda Y, Mori M, Kajiyama K, Haraguchi Y, Sasaki O, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Br J Cancer. 1995 Jul;72(1):189-92. doi: 10.1038/bjc.1995.301.
The immunohistochemical expression of tenascin was examined in the normal adult mucosa of the stomach, primary tumours and lymph node metastases of gastric cancer patients. In normal gastric tissue tenascin was expressed in the muscularis mucosae, muscularis propria and vessel walls, however it was not expressed in either the mucosal connective tissue or the stromal tissue in the submucosal layer. In gastric cancer, tenascin was expressed in 35 of 85 primary tumours, and in 8 of 25 metastases in lymph nodes. Tenascin was located in the fibrous stroma surrounding foci of cancer. The expression of tenascin in the primary tumour did not correlate with the depth of invasion, lymph node metastasis or prognosis. Tenascin appears during the process of either malignant transformation or tumour progression in gastric cancer, and the positive expression of tenascin may be useful as a stromal marker for the early detection of gastric cancer.
在胃癌患者的正常成人胃黏膜、原发性肿瘤及淋巴结转移灶中检测了肌腱蛋白的免疫组化表达。在正常胃组织中，肌腱蛋白表达于黏膜肌层、固有肌层和血管壁，但在黏膜结缔组织或黏膜下层的基质组织中均未表达。在胃癌中，85例原发性肿瘤中有35例表达肌腱蛋白，25例淋巴结转移灶中有8例表达。肌腱蛋白位于癌灶周围的纤维基质中。原发性肿瘤中肌腱蛋白的表达与浸润深度、淋巴结转移或预后均无相关性。肌腱蛋白出现在胃癌的恶性转化或肿瘤进展过程中，肌腱蛋白的阳性表达可能作为胃癌早期检测的一种基质标志物。
