Matkevich V A, Simonenkov A P, Ostapenko Iu N, Zavadovskiĭ M M, Drendel' S D, Kashtanova I S
Anesteziol Reanimatol. 1995 May-Jun(3):16-20.
Ninety-five patients with acute poisonings with psychotropic agents, barbiturates, amitriptyline, leponex, cholinolytics, and organophosphorus insecticides were treated by gastro-enteroadsorption making use of activated coal. In order to enhance propulsive function of the gastrointestinal tract, serotonin adipinate was repeatedly administered in a dose of 5 to 20 mg. Evacuation of the enteroadsorbent in the rectum was enhanced fivefold in comparison with a control group of similar patients administered traditional drugs (proserine, pituitrin, cerucal). As a result of such therapy, the toxicogenic phase of poisoning was shortened and mortality in the observed group reduced twofold in patients poisoned with psychotropic agents, 5.4 times in those with barbiturate poisoning, and 3.5 times in those with organophosphorus poisoning.
95例因精神药物、巴比妥类药物、阿米替林、氯氮平、胆碱能阻滞剂及有机磷杀虫剂急性中毒的患者，采用活性炭进行胃肠吸附治疗。为增强胃肠道的推进功能，反复给予5至20毫克剂量的己二酸血清素。与给予传统药物（新斯的明、垂体后叶素、西卢卡）的相似患者对照组相比，直肠中肠吸附剂的排出量增加了五倍。经过这样的治疗，中毒的毒性发生期缩短，观察组中因精神药物中毒的患者死亡率降低了两倍，巴比妥类药物中毒患者降低了5.4倍，有机磷中毒患者降低了3.5倍。
