Savina A S, Il'iashenko K K
Anesteziol Reanimatol. 1995 May-Jun(3):10-3.
Efficacy of dobutrex was assessed in 75 patients with grave poisonings. In 45 of these poisoning with cardiotoxic agents was complicated by acute heart failure and in 30 poisoning with psychopharmacological agents involved secondary disorders of cardiac contractile function. A sharp reduction of cardiac contractile function and output were observed in all the cases. Treatment efficacy was assessed by monitoring the parameters of central hemodynamics and by phase analysis of left-ventricular systole by rheopolycardiography with recording by mingograf-82. The results indicated a rapid and effective correction of decreased cardiac contractility and increase of cardiac output. The dose-effective concentration of dobutrex in the blood needed for the treatment of acute heart failure was from 10 to 17.5 micrograms/kg/min. Arterial pressure, cardiac contractility, and cardiac output stabilized within 4 to 6 h. After poisoning with psychopharmacological agents cardiac contractility recovered in 3-3.5 h. The dose-effective concentration of dobutrex in the blood was 5 micrograms/kg/min. Dobutrex is a highly active cardiotonic agent for the treatment of critical states developing in the aforesaid poisonings.
在75例严重中毒患者中评估了多巴酚丁胺的疗效。其中45例因心脏毒性药物中毒并发急性心力衰竭，30例因精神药理药物中毒伴有心脏收缩功能继发性障碍。所有病例均观察到心脏收缩功能和心输出量急剧下降。通过监测中心血流动力学参数以及用明胶记录仪-82记录经流变心电图对左心室收缩期进行相位分析来评估治疗效果。结果表明，心脏收缩力下降得到快速有效纠正，心输出量增加。治疗急性心力衰竭所需的血液中多巴酚丁胺有效浓度为10至17.5微克/千克/分钟。动脉压、心脏收缩力和心输出量在4至6小时内稳定。精神药理药物中毒后，心脏收缩力在3 - 3.5小时内恢复。血液中多巴酚丁胺有效浓度为5微克/千克/分钟。多巴酚丁胺是一种高效强心剂，用于治疗上述中毒所引发的危急状态。
