Meledin V Iu, Sentsov V G, Brusin K M
Anesteziol Reanimatol. 1995 May-Jun(3):23-5.
Cardio- and hemodynamics were examined in 56 patients with acute suicidal poisonings with amitriptyline, a tricyclic antidepressant, in order to select and optimize the main agents for intensive care of disorders developing in the circulatory system. Adsorption detoxication in parallel with adequate correction of volemic disorders was found to be advisable. A possibility of hemodynamic stabilization in patients with normo- and tachycardia without sharp hypotonia by nonspecific antidotes proserine or obsidan was shown, and by inotropic support with dobutrex in patients with signs of exotoxic shock. The mechanisms underlying the efficacy of therapy are discussed.
对56例急性自杀性三环类抗抑郁药阿米替林中毒患者的心脏和血流动力学进行了检查，以选择并优化用于循环系统疾病重症监护的主要药物。发现并行进行吸附解毒和充分纠正容量紊乱是可取的。结果表明，对于无明显低血压的正常心率和心动过速患者，非特异性解毒剂毒扁豆碱或奥昔旦能实现血流动力学稳定；对于有外源性中毒性休克迹象的患者，多巴酚丁胺能起到正性肌力支持作用。文中还讨论了治疗效果的潜在机制。
