Vollmer G
Institut für Biochemische Endokrinologie, Medizinische Universität, Lübeck, Germany.
Biochem Cell Biol. 1994 Nov-Dec;72(11-12):505-14. doi: 10.1139/o94-068.
Cytotactin/tenascin/hexabrachion, now referred to as tenascin-C (TN-C), is a hexameric glycoprotein of the extracellular matrix of mesenchymal tissue constituents. A high expression was found in embryonic development and during carcinogenesis of almost all organs. TN-C expression by the mesenchyme thereby appears to be induced by paracrine-acting, epithelial-derived (growth) factors. In normal adult organs there is little, if any, TN-C expression. In the human endometrium for instance, tenascin expression is low in the normal proliferative endometrium and undetectable in the normal secretory endometrium. In this paper, the appearance and expression of TN-C in hormone-dependent tissues, regressing hormone-dependent tissues, and tumors of the endometrium, breast and prostate is reviewed. Further, the regulation of TN-C expression is summarized and possible functions of TN-C during regression and carcinogenesis of hormone-dependent tissues are discussed.
细胞趋触蛋白/腱生蛋白/六臂蛋白，现称为腱生蛋白-C（TN-C），是间充质组织成分细胞外基质中的一种六聚体糖蛋白。在胚胎发育以及几乎所有器官的癌变过程中均发现其高表达。间充质细胞中TN-C的表达似乎是由旁分泌作用的上皮来源（生长）因子诱导的。在正常成体器官中，TN-C表达极少，即便有也微乎其微。例如，在人类子宫内膜中，正常增殖期子宫内膜的腱生蛋白表达较低，而在正常分泌期子宫内膜中则检测不到。本文综述了TN-C在激素依赖性组织、激素依赖性消退组织以及子宫内膜、乳腺和前列腺肿瘤中的出现与表达情况。此外，总结了TN-C表达的调控，并讨论了TN-C在激素依赖性组织消退和癌变过程中的可能作用。
