Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.

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作者信息

Akira S, Nishio Y, Tanaka T, Inoue M, Matsusaka T, Wang X J, Wei S, Yoshida N, Kishimoto T

机构信息

Institute for Molecular and Cellular Biology, Osaka University, Japan.

出版信息

Ann N Y Acad Sci. 1995 Jul 21;762:15-27; discussion 27-8. doi: 10.1111/j.1749-6632.1995.tb32310.x.

DOI:10.1111/j.1749-6632.1995.tb32310.x

PMID:7545362

Abstract

摘要

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Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.

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Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation.通过白细胞介素6信号转导子gp130的胞质结构域对急性期反应因子/信号转导子和转录激活子3（STAT3）及信号转导子和转录激活子1（STAT1）的差异性激活。I. 介导STAT1激活的新型磷酸酪氨酸基序的定义。

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