Maswood S, Stewart G, Uphouse L
Department of Biology, Texas Woman's University, Denton 76204, USA.
Pharmacol Biochem Behav. 1995 Aug;51(4):807-13. doi: 10.1016/0091-3057(95)00038-x.
Effects of the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.04, 0.25, or 1.0 mg/kg), on hypothalamic serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and their ratio were determined in adult male rats and in diestrous, proestrous, and estrous female rats. Consistent with its action at the somatodendritic 5-HT1A autoreceptor, 8-OH-DPAT decreased the 5-HIAA/5-HT ratio, but the decrease was least evident in proestrous females and in males. Similar to hypothalamic tissue, there was also a decline in the 5-HIAA/5-HT ratio in the hippocampus after treatment with 0.25 mg/kg 8-OH-DPAT. When ovariectomized rats were treated with oil or estradiol benzoate followed 48 h later by oil or progesterone, 0.25 mg/kg 8-OH-DPAT produced a decrease in the hypothalamic 5-HIAA/5-HT ratio in every group except those rats treated with progesterone without estrogen priming. Treatment with estradiol benzoate increased hypothalamic 5-HIAA, and both progesterone and 8-OH-DPAT reduced the metabolite to the level of the ovariectomized control. These results suggest that both estrogen and progesterone contribute to an estrous cycle modulation of the 5-HT1A somatodendritic autoreceptor.
在成年雄性大鼠以及处于动情间期、动情前期和动情期的雌性大鼠中，测定了5-羟色胺1A（5-HT1A）激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT；0.04、0.25或1.0毫克/千克）对下丘脑5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）及其比值的影响。与它作用于树突-胞体5-HT1A自身受体的效应一致，8-OH-DPAT降低了5-HIAA/5-HT比值，但这种降低在动情前期雌性大鼠和雄性大鼠中最不明显。与下丘脑组织类似，用0.25毫克/千克8-OH-DPAT处理后，海马体中的5-HIAA/5-HT比值也下降。当对去卵巢大鼠先给予油剂或苯甲酸雌二醇，48小时后再给予油剂或孕酮时，除了未用雌激素预处理而仅用孕酮处理的大鼠外，0.25毫克/千克8-OH-DPAT使每组大鼠下丘脑的5-HIAA/5-HT比值都降低。苯甲酸雌二醇处理可增加下丘脑5-HIAA，孕酮和8-OH-DPAT都将该代谢产物降低到去卵巢对照水平。这些结果表明，雌激素和孕酮都参与了对5-HT1A树突-胞体自身受体的动情周期调节。
