苯甲酸雌二醇对5-HT1A受体激动剂作用的剂量依赖性效应。
Dose-dependent effects of estradiol benzoate on 5-HT1A receptor agonist action.
作者信息
Jackson A, Uphouse L
机构信息
Department of Biology, Texas Woman's University, Denton 76204, USA.
出版信息
Brain Res. 1998 Jun 15;796(1-2):299-302. doi: 10.1016/s0006-8993(98)00238-8.
The lordosis-inhibiting effects of the 5-HT1A receptor agonist, (+/-)8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined in ovariectomized rats, hormone primed with 2.5, 7.5, or 25 micrograms estradiol benzoate plus 500 micrograms progesterone. 8-OH-DPAT (50, 100 or 200 ng per bilateral site) infused into the ventromedial nucleus of the hypothalamus (VMN), inhibited lordosis behavior in all hormone-treated conditions. However, animals primed with 2.5 micrograms estradiol benzoate were significantly more affected by the infusion than rats primed with 7.5 or 25 micrograms of the hormone. These findings strengthen prior speculations that 5-HT1A receptor function is modulated by estrogen.
在切除卵巢并用2.5微克、7.5微克或25微克苯甲酸雌二醇加500微克孕酮进行激素预处理的大鼠中，研究了5-羟色胺1A（5-HT1A）受体激动剂（±）8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）对脊柱前凸的抑制作用。将8-OH-DPAT（每双侧位点50、100或200纳克）注入下丘脑腹内侧核（VMN），在所有激素处理条件下均抑制了脊柱前凸行为。然而，用2.5微克苯甲酸雌二醇预处理的动物比用7.5微克或25微克该激素预处理的大鼠受注射的影响明显更大。这些发现强化了先前关于雌激素调节5-HT1A受体功能的推测。
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