Montesinos M C, Ubeda A, Terencio M C, Payá M, Alcaraz M J
Departamento de Farmacologia de la Universidad de Valencia, Spain.
Z Naturforsch C J Biosci. 1995 Jul-Aug;50(7-8):552-60. doi: 10.1515/znc-1995-7-813.
A number of free radical generating systems were used to investigate the antioxidant properties and structure-activity relationships of a series of monohydroxylated and dihydroxylated flavones. Ortho-dihydroxylated flavones showed the highest inhibitory activity on enzymic and non-enzymic microsomal lipid peroxidation as well as on peroxyl radical scavenging. Most flavones were weak scavengers of hydroxyl radical, while ortho-dihydroxylated flavones interacted with superoxide anion generated by an enzymic system or by human neutrophils. This series of compounds did not exert cytotoxic effects on these cells. Scavenging of superoxide and peroxyl radicals may determine the antioxidant properties of these active flavones.
使用了多种自由基生成系统来研究一系列单羟基和二羟基黄酮的抗氧化特性及构效关系。邻二羟基黄酮对酶促和非酶促微粒体脂质过氧化以及过氧自由基清除表现出最高的抑制活性。大多数黄酮是羟基自由基的弱清除剂，而邻二羟基黄酮与酶系统或人中性粒细胞产生的超氧阴离子相互作用。这一系列化合物对这些细胞没有细胞毒性作用。超氧自由基和过氧自由基的清除可能决定了这些活性黄酮的抗氧化特性。
