Prats G, Llovet T
Departament de Genètica i de Microbiologia, Unitat docent de Sant Pau, Universitat Autònoma de Barcelona.
Microbiologia. 1995 Mar;11(1):91-6.
Enteroinvasive Escherichia coli (EIEC) is an intestinal pathogen causing enteritis, with a similar pathogenic mechanism to that of Shigella, which causes an epithelial invasion of the large bowel leading to inflammation and ulceration of the mucosa. The patients often develop the symptoms of bacillary dysentery. The EIEC strains are atypical in their biochemical reactions and may ferment lactose late or not at all, are lysine decarboxilase negative, and non motile. In addition, most EIEC strains express somatic antigens which are either strongly related or identical to Shigella antigens. EIEC invasion is mediated by a large plasmid (140 MDa) coding for the production of several outer membrane proteins involved in invasiveness. These strains have been isolated with some regularity in South America, the Extreme Orient, and Eastern Europe. In Spain the incidence of enteroinvasive E. coli is extraordinarily low (0.2%), the serogroup O124 being the most frequently isolated. EIEC enteritis has been associated to sporadic cases occurring in travellers. Occasional outbreaks related to ingestion of contaminated water or food and person to person have been reported.
侵袭性大肠杆菌（EIEC）是一种引起肠炎的肠道病原体，其致病机制与志贺氏菌相似，可导致大肠上皮侵袭，进而引起黏膜炎症和溃疡。患者常出现细菌性痢疾症状。EIEC菌株在生化反应方面表现不典型，可能很晚才发酵乳糖或根本不发酵，赖氨酸脱羧酶阴性，且无动力。此外，大多数EIEC菌株表达的菌体抗原与志贺氏菌抗原密切相关或完全相同。EIEC的侵袭由一个大质粒（140 MDa）介导，该质粒编码几种与侵袭性有关的外膜蛋白的产生。这些菌株在南美洲、远东地区和东欧有一定的分离率。在西班牙，侵袭性大肠杆菌的发病率极低（0.2%），O124血清型是最常分离到的。EIEC肠炎与旅行者中散发病例有关。曾有因摄入受污染的水或食物以及人与人之间传播而导致的偶尔暴发的报道。
