[有机磷杀虫剂奥呋那对体外培养细胞代谢的影响]
[Effects of the organophosphorus insecticide Ofunack on the metabolism of cells cultured in vitro].
作者信息
Rodrigues M A, Puga F R
出版信息
Arq Inst Biol (Sao Paulo). 1978 Oct-Dec;45(4):287-90.
PMID:754677
Abstract
The effects of "ofunack (0,0-diethyl-0-(3-oxo-2-phenyl-2H-pyridazine-6-y1) phosphorothionate on the metabolism of IB-RS-2 cell line were studied. "Ofunack" stimulates cell growth and protein synthesis till 24 hours after its addition to the maintenance medium. Otherwise after this time "ofunack" induces an inhibition both on cell growth and on protein synthesis. This insecticide also inhibits the synthesis of RNA and DNA.
摘要
研究了“奥弗那克（0,0 - 二乙基 - 0 -（3 - 氧代 - 2 - 苯基 - 2H - 哒嗪 - 6 - 基）硫代磷酸酯）对IB - RS - 2细胞系代谢的影响。“奥弗那克”在添加到维持培养基后24小时内刺激细胞生长和蛋白质合成。在此时间之后，“奥弗那克”对细胞生长和蛋白质合成均诱导抑制作用。这种杀虫剂还抑制RNA和DNA的合成。
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