Brutel de la Rivière A, Knaepen P, Van Swieten H, Vanderschueren R, Ernst J, Van den Bosch J
Department of Cardiopulmonary Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Eur J Cardiothorac Surg. 1995;9(6):310-3; discussion 313-4. doi: 10.1016/s1010-7940(05)80188-5.
From 1979 to 1993, 79 patients underwent pulmonary resection for lung cancer and a concomitant cardiac operation using extracorporeal circulation. There were 75 men and 4 women with a mean age of 65 years (range 52-77). Cardiac procedures consisted of coronary artery bypass grafting (CABG) in 69 patients (three redos), aortic valve replacement in 7 (2 combined with CABG), mitral valve repair in 1 (combined with CABG) and other in 2. In CABG cases the mean number of distal anastomoses was 4.0. Pulmonary resection included bilateral lobectomy in 1 patient, sleeve lobectomy in 3, pneumonectomy in 6, bilobectomy in 5, lobectomy in 60 and segmental resection in 4. Postoperatively 52 patients were stage I (65.8%), 18 stage II (22.8%) and 9 stage III a. Histology was squamous cell carcinoma in 48 patients (61%) and adenocarcinoma in 24 patients (30%). The hospital mortality was 6.3% (n = 5). Re-exploration for bleeding was necessary in seven patients. Follow-up was complete for all patients. The estimated mean survival for all patients (including hospital deaths) was 58 months. Two- and five-year survival rates were 62% and 42% with 45 and 22 patients, respectively, under surveillance. Lung cancer accounted for 64% of the late deaths. We conclude that pulmonary resection for lung cancer in patients undergoing a concomitant cardiac operation can be performed safely with low operative morbidity and mortality and good long-term survival.
1979年至1993年期间,79例患者接受了肺癌肺切除术,并同期使用体外循环进行心脏手术。其中男性75例,女性4例,平均年龄65岁(范围52 - 77岁)。心脏手术包括69例患者进行冠状动脉旁路移植术(CABG)(3例再次手术),7例进行主动脉瓣置换术(2例合并CABG),1例进行二尖瓣修复术(合并CABG),2例进行其他手术。在CABG病例中,远端吻合的平均数量为4.0。肺切除术包括1例双侧肺叶切除术,3例袖状肺叶切除术,6例全肺切除术,5例双肺叶切除术,60例肺叶切除术和4例肺段切除术。术后52例患者为Ⅰ期(65.8%),18例为Ⅱ期(22.8%),9例为Ⅲa期。组织学检查显示,48例患者(61%)为鳞状细胞癌,24例患者(30%)为腺癌。医院死亡率为6.3%(n = 5)。7例患者需要再次手术止血。所有患者均完成随访。所有患者(包括医院死亡患者)的估计平均生存期为58个月。在接受监测的45例和22例患者中,2年和5年生存率分别为62%和42%。肺癌占晚期死亡病例的64%。我们得出结论,对于同期进行心脏手术的患者,肺癌肺切除术可以安全进行,手术发病率和死亡率低,长期生存率良好。