Lowe N M, Hall E J, Anderson R S, Batt R M, Jackson M J
Department of Medicine, University of Liverpool.
Br J Nutr. 1995 Jul;74(1):69-76. doi: 10.1079/bjn19950107.
The short-term kinetics of Zn turnover were studied in Irish setters with gluten-sensitive enteropathy and control dogs following intravenous injection of 0.25 mg 96.5% enriched 70ZnCl2. The 70Zn enrichment of serum was found closely to obey two-compartment kinetics and the derived two-compartment decay equation was used to calculate the size and turnover of the two initial rapidly exchanging pools of body Zn. In normal Irish setters isotopic Zn initially equilibrates with a pool (a) of size 1.27 (SD 0.46) mumol/kg and then with a second pool (b) of size 6.83 (SD 1.72) mumol/kg. The fractional turnover of pool (b) was approximately one eighth that of pool (a). Enteropathic dogs showed no reduction in the size of either rapidly exchangeable Zn pool, reduction in serum Zn concentration or abnormality in Zn balance and hence these results do not support the possibility of an underlying Zn deficiency in this disorder.
在给患有麸质敏感性肠病的爱尔兰雪达犬和对照犬静脉注射0.25毫克96.5%富集的70ZnCl2后，研究了锌周转的短期动力学。发现血清中的70Zn富集密切遵循两室动力学，并使用推导的两室衰变方程来计算体内锌的两个初始快速交换池的大小和周转率。在正常的爱尔兰雪达犬中，同位素锌最初与大小为1.27（标准差0.46）微摩尔/千克的池（a）平衡，然后与大小为6.83（标准差1.72）微摩尔/千克的第二个池（b）平衡。池（b）的分数周转率约为池（a）的八分之一。患肠病的犬在快速可交换锌池的大小、血清锌浓度降低或锌平衡异常方面均未出现降低，因此这些结果不支持该疾病存在潜在锌缺乏的可能性。
