Veterinary Medical Center, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku, Ourai Kita, Izumisano, Osaka 598-8531, Japan.
Laboratory of Cell Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku, Ourai Kita, Izumisano, Osaka 598-8531, Japan.
J Vet Med Sci. 2020 Jun 24;82(6):759-763. doi: 10.1292/jvms.20-0109. Epub 2020 Apr 16.
Human patients with inflammatory bowel disease may have poor prognosis with hypozincemia. However, there are limited data on zinc concentrations in the blood of dogs with lymphocytic-plasmacytic enteritis (LPE). The purpose of this study was to investigate the serum zinc concentration in dogs with LPE and its influence on disease severity and prognosis. Thirty-five dogs with LPE were recruited. Serum zinc concentration was measured using atomic absorption spectrometry. Hypozincemia was observed in 18/35 (51%) dogs with LPE. Serum zinc concentration was inversely correlated with histological and clinical severities. Overall survivals were significantly shorter in dogs with hypozincemia than in those without it. These findings suggest that serum zinc concentration is a useful biomarker for LPE severity and prognosis in dogs.
患有炎症性肠病的人类患者可能会因低血锌而预后不良。然而，关于淋巴细胞性浆细胞性肠炎 (LPE) 犬血液中的锌浓度的数据有限。本研究旨在调查 LPE 犬的血清锌浓度及其对疾病严重程度和预后的影响。 共招募了 35 只患有 LPE 的犬。 使用原子吸收光谱法测量血清锌浓度。 观察到 18/35 (51%) 只患有 LPE 的犬存在低血锌症。 血清锌浓度与组织学和临床严重程度呈负相关。 低血锌症犬的总生存率明显短于无低血锌症犬。 这些发现表明，血清锌浓度是犬 LPE 严重程度和预后的有用生物标志物。
