Shirai M, Motoya M, Funahashi H, Masaoka T, Yamamoto M, Arishima K, Akahori F, Eguchi Y
Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
J Vet Med Sci. 1995 Jun;57(3):497-8. doi: 10.1292/jvms.57.497.
Pregnant rats on day 21 of gestation received a subcutaneous injection of paraquat (25 mg/kg). Two hr later, some fetuses of these rats received a subcutaneous injection of prostaglandin E2 (PGE2). The caliber of the ductus arteriosus (DA) of fetuses was measured 1 hr later. The DA of fetuses of paraquat-treated pregnant rats was significantly constricted compared with that of fetuses of control pregnant rats given physiological saline. However, the DA of PGE2-treated fetuses of paraquat-treated pregnant rats had a caliber comparable to that of control rats. The maternal plasma PGE2 level decreased following paraquat treatment. These results suggest that the decrease of maternal PGE2 level results in a constriction of the DA of fetuses.
妊娠第21天的孕鼠接受皮下注射百草枯（25毫克/千克）。两小时后，这些孕鼠的部分胎儿接受皮下注射前列腺素E2（PGE2）。1小时后测量胎儿动脉导管（DA）的管径。与给予生理盐水的对照孕鼠的胎儿相比，百草枯处理的孕鼠的胎儿的DA明显收缩。然而，百草枯处理的孕鼠经PGE2处理的胎儿的DA管径与对照大鼠相当。百草枯处理后母体血浆PGE2水平降低。这些结果表明，母体PGE2水平的降低导致胎儿DA收缩。
