Kopala L C, Good K, Honer W G
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Biol Psychiatry. 1995 Jul 1;38(1):57-63. doi: 10.1016/0006-3223(94)00224-Q.
Previously we reported olfactory deficits in young male but not female patients with schizophrenia. In the present report, olfactory identification ability in pre- and postmenopausal women with schizophrenia and normal control subjects was assessed using the University of Pennsylvania Smell Identification Test (UPSIT). Additionally, serum estradiol levels were measured on the same 2 days as smell testing was completed. Olfactory deficits were observed in pre- and postmenopausal women with schizophrenia but were more pronounced in the postmenopausal patients. Regarding estradiol levels, women with schizophrenia had lower estradiol levels than did normal control subjects. The findings of this study indicate that olfactory deficits do exist in women with schizophrenia and may be accentuated by estrogen depletion.
此前我们报道过，患有精神分裂症的年轻男性患者存在嗅觉缺陷，但女性患者不存在。在本报告中，我们使用宾夕法尼亚大学嗅觉识别测试（UPSIT）对患有精神分裂症的绝经前和绝经后女性以及正常对照受试者的嗅觉识别能力进行了评估。此外，在完成嗅觉测试的同一天测量血清雌二醇水平。患有精神分裂症的绝经前和绝经后女性均存在嗅觉缺陷，但在绝经后患者中更为明显。关于雌二醇水平，患有精神分裂症的女性的雌二醇水平低于正常对照受试者。本研究结果表明，患有精神分裂症的女性确实存在嗅觉缺陷，并且可能因雌激素缺乏而加剧。
