脑脊液中α1-抗糜蛋白酶水平与晚发型阿尔茨海默病密切相关。

Alpha 1-antichymotrypsin level in cerebrospinal fluid is closely associated with late onset Alzheimer's disease.

作者信息

Harigaya Y, Shoji M, Nakamura T, Matsubara E, Hosoda K, Hirai S

机构信息

Department of Neurology, Gunma University School of Medicine, Maebashi.

出版信息

Intern Med. 1995 Jun;34(6):481-4. doi: 10.2169/internalmedicine.34.481.

DOI:10.2169/internalmedicine.34.481

PMID:7549128

Abstract

The levels of alpha 1-antichymotrypsin (ACT) in cerebrospinal fluid (CSF) from 66 sporadic Alzheimer's disease (AD) patients and 54 normal controls were measured by enzyme immunoassay and compared. There was no correlation (r = 0.259, n = 54) between the ACT level and normal aging. The levels of ACT were significantly higher in the total AD group (p < 0.01) than in the normal control group. Dividing AD patients into early onset AD (n = 27) and late onset AD groups (n = 39), the mean level of CSF ACT in the late onset AD group was significantly higher than that in the normal control group (p < 0.001) and that in the early onset AD group (p < 0.01). Thus, the level of ACT in CSF is closely associated with late onset AD.

摘要

通过酶免疫测定法测量并比较了66例散发性阿尔茨海默病（AD）患者和54例正常对照者脑脊液（CSF）中α1 - 抗糜蛋白酶（ACT）的水平。ACT水平与正常衰老之间无相关性（r = 0.259，n = 54）。AD患者总组中ACT水平显著高于正常对照组（p < 0.01）。将AD患者分为早发型AD组（n = 27）和晚发型AD组（n = 39），晚发型AD组CSF中ACT的平均水平显著高于正常对照组（p < 0.001）和早发型AD组（p < 0.01）。因此，CSF中ACT水平与晚发型AD密切相关。