衰老与阿尔茨海默病：脑脊液中的蛋白酶抑制剂

Aging and Alzheimer's disease: protease inhibitors in cerebrospinal fluid.

作者信息

Delamarche C, Berger F, Gallard L, Pouplard-Barthelaix A

机构信息

INSERM U 298, Centre Hospitalier Regional, Angers, France.

出版信息

Neurobiol Aging. 1991 Jan-Feb;12(1):71-4. doi: 10.1016/0197-4580(91)90042-i.

DOI:10.1016/0197-4580(91)90042-i

PMID:2002886

Abstract

Recent advances suggested that proteases and their inhibitors could be implicated in the genesis and/or maturation of insoluble deposits associated with Alzheimer's disease (AD). This study was designed to measure the level of alpha 1-antichymotrypsin (ACT) and alpha 1-antitrypsin (AT) in cerebrospinal fluid (CSF) of patients with AD and nondemented humans at various ages. Our analysis failed to demonstrate a significant relationship between inhibitor content and disease. However, a positive correlation was observed between age and the ACT level for the normal control group. Such observation suggests a specific association of ACT with the mechanisms of brain aging.

摘要

最近的研究进展表明，蛋白酶及其抑制剂可能与阿尔茨海默病（AD）相关的不溶性沉积物的形成和/或成熟有关。本研究旨在测量不同年龄段的AD患者和非痴呆人群脑脊液（CSF）中α1-抗糜蛋白酶（ACT）和α1-抗胰蛋白酶（AT）的水平。我们的分析未能证明抑制剂含量与疾病之间存在显著关系。然而，在正常对照组中，观察到年龄与ACT水平呈正相关。这种观察结果表明ACT与脑老化机制存在特定关联。